• Posted on March 26, 2011 10:29 am
    By Max
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    New Treatment May Prevent Deadly Radiation Sickness By Jeremy Hsu, InnovationNewsDaily Senior Writer 23 March 2011 12:06 PM ET ________________________________________ Radiation sickness has haunted humanity since the atomic bombs dropped, killed entire teams of firefighters at the Chernobyl nuclear plant disaster and worries workers trying to fix the Fukushima reactor in Japan. But certain death from a high dose of radiation may finally vanish with a stem cell-based cellular treatment that protects the human body when it is most defenseless. Such a therapy might even work up to several days after exposure to dangerous levels of radiation, according to Ram Mandalam, president and CEO of Cellerant Therapeutics. His company has a U.S. government contract worth up to $153.2 million to develop the treatment known as CLT-008. "It could be given three to five days post-exposure and help with survival," Mandalam said. "That's important in cases such as what's happening in Japan, where people may not learn the level [of radiation] they have been exposed to until 24 to 48 hours later." About 50 to 100 Japanese workers risked radiation and explosions to prevent complete meltdown of nuclear reactors at the Fukushima plant. The workers wore heavy protective suits and rotated in and out to minimize exposure. Japanese authorities also handed potassium iodide pills to citizens as a preventive measure against radioactive iodine — just one of several radioactive materials that can be released in nuclear plant disasters. But no current treatment exists for radiation sickness, which is also known as acute radiation syndrome. CLT-008 could become the first such treatment. It deploys precursor cells derived from adult stem cells that can mature into platelets, red blood cells and certain white blood cells. The latter provide a crucial line of defense in the body's immune system for fighting off infections from bacteria and fungi. That matters because infections are what often end up killing victims of radiation sickness. High radiation doses destroy the bone marrow that produces white blood cells and leave the victim with virtually no immune system — unless he or she can get a temporary defensive boost from an outside source. "Most products being built as countermeasures [for radiation] will try to prevent the death of a person's own cells," Mandalam told InnovationNewsDaily. "In our case, we have a product that provides cells to the person independent of the person's own cells." Cellerant Therapeutics first considered CLT-008 as a way to boost the immune system of patients who receive radiation as part of chemotherapy for cancer. But the biotech company soon found that the treatment worked well enough in its two Phase I clinical safety trials to possibly defend against higher levels of radiation. The realization led to preclinical studies with animals that showed how CLT-008 could still provide protection days after the first radiation exposure. If all goes well, Mandalam expects to have enough trial data to begin looking at getting approval from the Food and Drug Administration in about five years. The company's current contract came from the Biomedical Advanced Research and Development Authority (BARDA), a federal agency that manages Project BioShield and looks to develop medical countermeasures for biological, chemical and nuclear dangers.

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  • Posted on March 16, 2011 5:41 pm
    By Max
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    How To Protect Yourself From Radiation Exposure Mon Mar 14 2011 20:13 by Curt Hendrix, M.S. C.C.N. C.N.S Because of what is occurring in Japan, many people are wondering what they could do to protect themselves in the event that dangerous levels of radiation were to make their way into the United States. The following is a consensus of options that may be protective without being dangerous. It’s important to understand that some of these options have not been studied in large, well organized trials but come about as a result of the reported experience of countries, scientists and physicians who had to deal with dangerous levels of radiation and their effects on the populations exposed to them. There are two types of radiation, according to Lita Lee, author of Radiation Protection Manual. They are ionizing and non-ionizing radiation. The ionizing radiation is more damaging because it is of a higher energy than non-ionizing radiation and produces charged particles called ions, either negative ions (the good “guys”) or positive ions (the bad ones). Ionizing radiation is produced from nuclear bombs, nuclear reactors, medical and dental x-rays, and is the type of radiation used to irradiate food. The non-ionizing radiation includes electromagnetic radiation produced by electric current, radio waves, microwave ovens, radar stations, television (cathode ray tube), video display terminals (VDT’s) computers, high voltage lines, infrared and fluorescent lights, and sunlamps (e.g. tanning booths which emit ultraviolet light). #1- Potassium Iodide (KI) – Many are reading about potassium iodide being handed out in Japan because of radiation levels. Potassium iodide may protect just the thyroid gland against exposure to radioactive iodine that occurs when radiation levels increase. KI will probably not help with radiation damage in other parts of the body. The FDA has approved two different forms of KI—tablets and liquid—that people can take by mouth after a nuclear radiation emergency. Tablets come in two strengths, 130 milligram (mg) and 65 mg. The tablets are scored so they may be cut into smaller pieces for lower doses. Each milliliter (mL) of the oral liquid solution contains 65 mg of KI. According to the FDA, the following doses are appropriate to take after internal contamination with (or likely internal contamination with) radioactive iodine: • Adults should take 130 mg (one 130 mg tablet OR two 65 mg tablets OR two mL of solution). • Women who are breastfeeding should take the adult dose of 130 mg. • Children between 3 and 18 years of age should take 65 mg (one 65 mg tablet OR 1 mL of solution). Children who are adult size (greater than or equal to 150 pounds) should take the full adult dose, regardless of their age. • Infants and children between 1 month and 3 years of age should take 32 mg (½ of a 65 mg tablet OR ½ mL of solution). This dose is for both nursing and non-nursing infants and children. • Newborns from birth to 1 month of age should be given 16 mg (¼ of a 65 mg tablet or ¼ mL of solution). This dose is for both nursing and non-nursing newborn infants. The protective effects of a dose of KI is about 24 hours. KI is available without a prescription, and a pharmacist can sell you KI brands that have been approved by the FDA #2- Glutathione and a potentially protective combination! We know radiation exposure causes approximately 3% of all cancers. This fact has been studied extensively. When you are exposed to radiation a very reactive type of free radical is formed called a “hydroxyradical”. Studies have shown glutathione’s (GSH) detoxification abilities play a key role in neutralizing hydroxyradicals and cancer specialists are now raising glutathione (GSH) levels in patients who are undergoing radiation therapy as part of their cancer treatment. Detoxification benefits from boosted glutathione (GSH) levels and helps cancer patients better tolerate their treatment. Studies have also been done around the world, from Switzerland to Spain to India to Germany, on the effect of glutathione (GSH) on radiation damage. Low levels of glutathione (GSH) were connected with an increased risk of developing cancer from radiation exposure. Patients undergoing cancer treatment experienced stronger side effects and greater injury from radiation therapy when they had low glutathione (GSH) levels. The immune system, have been shown to be better able to withstand radiation therapy when cancer specialists raised glutathione (GSH) prior to treatment. The implication here is…glutathione (GSH) does and will, to a greater degree, play a major role in the treatment of cancer by using detoxification to reduce the damaging effects of radiation. At the time of the atomic bombing, Tatsuichiro Akizuki, M.D. was Director of the Department of Internal Medicine at St. Francis’s Hospital in Nagasaki and he fed his staff and patients a strict diet of brown rice, miso and tamari soy soup, wakame, kombu and other seaweed, Hokkaido pumpkin, and sea salt. He also prohibited the consumption of sugar and sweets since they suppress the immune system. By imposing this diet on his staff and patients, no one succumbed to radiation poisoning whereas the occupants of hospitals located much further away from the blast incident suffered severe radiation fatalities. Much of this positive result has to do with the fact that the sea vegetables contain substances that bind radioactive particles and escort them out of the body. This is why seaweed sales usually skyrocket after radiation disasters, and why various seaweeds and algae are typically used to treat radiation victims. See this article for more information. In Chernobyl, for instance, spirulina was used to help save many children from radiation poisoning. By taking 5 grams of spirulina a day for 45 days, the Institute of Radiation Medicine in Minsk even proved that children on this protocol experienced enhanced immune systems, T-cell counts and reduced radioactivity. Israeli scientists have since treated Chernobyl children with doses of natural beta carotene from Dunaliella algae and proved that it helped normalize their blood chemistry. Chlorella algae, a known immune system builder and heavy metal detoxifier, has also shown radioprotective effects. Because they bind heavy metals, algae should therefore be consumed after exposure to any type of radioactive contamination. (Note: Marine phytoplankton is also a powerbul detoxifier and nourishing product. In 1968 a group of Canadian researchers at McGill University of Montreal, headed by Dr. Stanley Skoryna, actually set out to devise a method to counteract the effects of nuclear fallout. The key finding from their studies was that sea vegetables contained a polysaccharide substance, called sodium alginate, which selectively bound radioactive strontium and eliminated it from the body. Sodium alginate is found in many seaweeds, especially kelp, and since that time the Russians have been seriously researching the use of their own kelps from Vladivlostok, from which they have isolated the polysaccharide U-Fucoidan, which is another radioactive detoxifier. Because miso soup was so effective in helping prevent radiation sickness, the Japanese have also done research identifying the presence of an active ingredient called zybicolin, discovered in 1972, which acts as a binding agent to also detoxify and eliminate radioactive elements (such as strontium) and other pollutants from the body. The kelps and algaes aren’t the only natural foods with radio-detoxifying effects. In terms of fluids to drink, black and green tea have shown “radioprotective effects” whether consumed either before or after exposure to radiation. This anti-radiation effect was observed in several Japanese studies, and studies from China also suggest that the ingredients in tea are radioactive antagonists. In short, after any sort of radioactive exposure you want to be eating seaweeds and algaes along with almost any type of commercial heavy metal chelating formula to bind radioactive particles and help escort them out of the body. Whether you’re worried about depleted uranium, plutonium or other isotopes, this is the wise thing to do which can possibly help, and certainly won’t hurt. Many nutritional supplements have been developed for the purpose of detoxifying heavy metals, most of which contain the algaes and plant fibers and other binding substances. Basically, an anti-radiation diet should focus on the following foods: • Miso soup • Spirulina, chlorella and the algaes (kelp, etc.) • Brassica vegetables and high beta carotene vegetables • Beans and lentils • Potassium, calcium and mineral rich foods • High nucleotide content foods to assist in cellular repair including spirulina, chlorella, algae, yeast, sardines, liver, anchovies and mackerel • cod liver oil and olive oil • Avoid sugars and sweets and wheat • A good multivitamin/multimineral supplement Yet another benefit of the sea vegetables rarely discussed is their high mineral content, which is a bonus in the case of radioactive exposure. Consuming natural iodine, such as in the seaweeds, helps prevent the uptake of iodine-131 while iron inhibits the absorption of plutonium-238 and plutonium-239. Vitamin B-12 inhibits cobalt-60 uptake (used in nuclear medicine), zinc inhibits zinc-65 uptake and sulfur is preventative for sulfur-35 (a product of nuclear reactors) incorporation by the body. Since nuclear workers are potentially exposed to radioactive sulfur, this means that workers in the atomic power industry need a higher content of sulfur in their diet. MSM supplements provide a source of dietary sulfur, but thiol supplements such as cysteine, lipoic acid and glutathione serve double-duty in this area because they help detoxify the body and attack all sorts of other health problems as well. Curt Hendrix, M.S. C.C.N. C.N.S Originally published at MigRelief.com

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